بررسی تاثیر ایزوترتینویین بر بیماران جراحی رینوپلاستی

Introduction: Today, the rate of cosmetic surgeries is increasing in many countries, whereas many patient candidates for these surgeries either need isotretinoin due to skin problems or report a long-term use of isotretinoin. Due to possible repair problems caused by cosmetic surgery in patients consuming this medicine, many surgeons inevitably postpone surgery for at least 6 months. Is this intense of fear of repair problems necessary after all? The present research was an attempt to study the effects of isotretinoin on rhinoplasty patients during convalescence. Research Method: This research was conducted as a descriptive analytical study on 303 patient candidates for rhinoplasty in the control and experimental groups from 2012 to 2015. The experimental group patients were requested to consume isotretinoin from two weeks before surgery to two months following the surgery. A comparison was made between the two groups one, three, six, and twelve months after the surgery. Information was analyzed in SPSS version 21using the chi-square test, independent t test, Spearman’s test, and descriptive statistical tests. Findings: The chi-square statistical test indicated that satisfaction of patients of the experimental group in the first and third months following the surgery was significantly higher than the control group (p<0.01). Examination of the inside and outside of the nose suggests a lack of evidence of soft tissue repair disturbance and cartilaginous deformities. A total of 19 patients showed a need for reconstructive surgery during the study period (9 patients from the experimental group and 10 from the control group), and the reason for none of the reconstructive surgeries was logically related to intake of isotretinoin. Conclusion: Results of this research suggest that isotretinoin causes no evident disturbance to the recovery of rhinoplastic incisions and internal nose tissues including cartilages during rhinoplasty. Moreover, none of the members of the experimental group showed hypertrophic tissues and cartilaginous deformities, and the repair was satisfactory similar to the control group. However, patients receiving isotretinoin experienced a more satisfactory convalescence period.